Platelets, non-nucleated blood components first described over 130 years ago, are recognized as the primary cell regulating hemostasis and thrombosis. The vascular importance of platelets has been ...

Systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and small vessel vasculitis are three autoimmune diseases frequently manifested in the skin. They share common pathogenic features, ...

In addition to their well-defined roles in haemostasis and thrombosis, platelets contribute to immune defence by releasing antimicrobial mediators and initiating immune cell recruitment to injured ...

Thromboinflammation is a pathological condition characterized by the concurrence of thrombosis, inflammation, and vascular leakage/bleeding, which induce and exacerbate each other leading to ...

New research shows that activated platelets bind CD8-positive T cells via P-selectin and PSGL-1, directly suppressing their ...

Platelets have been shown to cover a broad range of functions. Besides their role in hemostasis, they have immunological functions and thus participate in the interaction between pathogens and host ...

Platelets play a vital role in normal hemostasis to stem blood loss at sites of vascular injury by tethering and adhering to sites of injury, recruiting other platelets and blood cells to the ...

Filip K. Swirski is in the Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA, and in the Department of Radiology, Harvard Medical School, Boston. Monocytes ...

Platelets are probably best known for their role in blood clotting, making scabs and related, if less salubrious, contributions to heart attacks and strokes. But these tiny, saucer-shaped blood cells ...

Acute inflammation is a highly regulated physiological process essential in defending the body against various external and internal threats. Any disruption in tissue homeostasis triggers the ...

The potential for a much longer shelf life means the life-saving treatment could be used in rural and remote areas as well as combat zones. Colleen Stieler-Hunt says blood platelets helped save her ...

When the polar vortex froze out residents in much the United States in January, it also sent chills through the U.S. blood system, especially for people who needed platelets. “If you are safely able ...